Molecular mechanisms of transport of substances across the blood-brain barrie as targets for pharmacological action. Part 2. Modern methods of delivery of pharmacological agents to the central nervous system

One of the unresolved problems on way to improving pharmacotherapy CNS diseases is development and creation technologies that allow drugs cross blood-brain barrier (BBB). The review discusses modern methods drug delivery CNS. advantages disadvantages main pharmacological strategies for directly overcoming BBB an alternative this are shown. New brain with damage (physical, chemical, etc.) without disruption structure (small molecules, cell-mediated transport, stem cells) considered. prospects use artificial nanosized transporters discussed. An strategy action structures (intranasal route) shown be promising. Possible mechanisms agents bypassing